AGN 196996( —— )

Catalog No. M32772 CAS No. 958295-17-5

AGN 196996 is a potent and selective inhibitor of RARα (Ki: 2 nM), exhibiting very low affinity for RARβ (Ki: 1087 nM) and RARγ (Ki: 8523 nM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

AGN 196996
Note

Research use only, not for human use.
Brief Description

AGN 196996 is a potent and selective inhibitor of RARα (Ki: 2 nM), exhibiting very low affinity for RARβ (Ki: 1087 nM) and RARγ (Ki: 8523 nM).
Description

AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM).IC50 value: 2 nM(Ki) Target: RARα antagonist AGN 196996 shows no activity in transactivation assays, but instead block the gene transcriptional activity induced by ATRA and other RAR agonists.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Autophagy
Target

Autophagy
Recptor

Autophagy | Retinoid Receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

958295-17-5
Formula Weight

482.32
Molecular Formula

C24H20BrNO5
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (518.33 mM; Ultrasonic )
SMILES

CCOc1c(Br)cc(cc1C(=O)c1ccc(C)cc1)C(=O)Nc1ccc(cc1)C(O)=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Hammond LA, et al. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. Br J Cancer. 2001 Aug 3;85(3):453-62.?

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