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AGN 196996
CAS No. 958295-17-5
AGN 196996( —— )
Catalog No. M32772 CAS No. 958295-17-5
AGN 196996 is a potent and selective inhibitor of RARα (Ki: 2 nM), exhibiting very low affinity for RARβ (Ki: 1087 nM) and RARγ (Ki: 8523 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 137 | In Stock |
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| 5MG | 211 | In Stock |
|
| 10MG | 316 | In Stock |
|
| 25MG | 530 | In Stock |
|
| 50MG | 771 | In Stock |
|
| 100MG | 1107 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAGN 196996
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NoteResearch use only, not for human use.
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Brief DescriptionAGN 196996 is a potent and selective inhibitor of RARα (Ki: 2 nM), exhibiting very low affinity for RARβ (Ki: 1087 nM) and RARγ (Ki: 8523 nM).
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DescriptionAGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM).IC50 value: 2 nM(Ki) Target: RARα antagonist AGN 196996 shows no activity in transactivation assays, but instead block the gene transcriptional activity induced by ATRA and other RAR agonists.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAutophagy
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TargetAutophagy
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RecptorAutophagy | Retinoid Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number958295-17-5
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Formula Weight482.32
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Molecular FormulaC24H20BrNO5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (518.33 mM; Ultrasonic )
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SMILESCCOc1c(Br)cc(cc1C(=O)c1ccc(C)cc1)C(=O)Nc1ccc(cc1)C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hammond LA, et al. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. Br J Cancer. 2001 Aug 3;85(3):453-62.?
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